Invasive pneumococcus diseases, 2007

Land active surveillance for invasive pneumonia Streptococcus (Pneumococcal) disease began in 2002, up from the metropolitan area, where active surveillance conducted since 1995. In 2007, 664 (12. 9 per 100,000 population) cases of invasive pneumococcal infections was not. By age group, the annual incidence per 100,000 was 30. 3 cases among children aged 0-4 years, 3. 7 cases among adults and children aged 5-39 years, 12. 9 cases among adults 40-64 years, and 40. 0 cases among adults aged 65 and older. In 2007, pneumonia is 381 (57%) cases of invasive pneumococcal infections in all cases (ie, infections accompanied by bacteremia or allocation of pneumococci from another sterile site, such as pleural fluid). Microbiemia without other foci of infection was 206 (31%) cases around the state. Pneumococcal meningitis has in 38 (6%) cases. Sixty-one (9%) patients with invasive pneumococcal infections died. In 1999, a year before the pediatric pneumococcal conjugated vaccine (Prevnar, Wyeth-Lederle [PCV-7]) was issued a license, the rate of invasive pneumococcal disease among children under 5 years in the metropolitan area was 111. 7 cases per 100 000. Over the years 2000-02 there was a great tendency to decrease morbidity in this age group (Fig. 4). Prices in each of the next four years were slightly higher, although there was a constant trend (Aug. 25 cases per 100,000 in 2003 .... 29 0 27 4, 23 March and 30 cases per 100,000 in 2004, 2005, 2006 and 2007, respectively (
). Based on the distribution of serotypes among order strattera isolates from these cases, this increase was limited to diseases caused by vaccine serotypes not (ie, serotypes, except for the seven included in PCV-7) [
]). This small degree of replacement of diseases associated with non-PCV-7 serotypes, similar to that observed in other parts of the country, it is more than offset by reduced disease caused by PCV-7 serotypes. This trend confirms the need for continuous monitoring, however, because further increase due to non vaccine serotypes possible. Figure 4 bids invasive pneumococcal infections among adults aged 65 years also showed serotypes included and not included in PCV-7. Reduction of morbidity in this age group, especially in sickness PCV-7 serotypes was observed elsewhere in the U.S. and probably due to the immunity from the use of PVC-7 in children. Among the cases overall, serotype not included in PCV-7 vaccine serotype 19A, is now often associated with invasive pneumococcal infections in Minnesota. From 615 strains represented in 2007 cases, one (1%) was isolated that are resistant to penicillin and 40 (6%) exhibited intermediate resistance nonmeningitis using Breakpoints (Note: CLSI penicillin breakpoints changed in 2008, related to MDH antibiohrammoy , p. 25-26), 96 isolates (16%) exhibited multidrug resistance (for example, high levels of resistance to two or more antibiotic classes). In year Informative see pneumoniae (pneumococcal infection) Full question.

